BENZYDAMINE HYDROCHLORIDE IMMOBILIZATION IN MULTILAYER STRUCTURES BASED ON LYOPHILIZED COMPOSITE POLYLACTIC ACID / POLY(Ε-CAPROLACTONE) SUBSTRATES

Abstract

In the present paper the polyelectrolyte multilayers (PEMs) deposited on lyophilized composite polylactic acid / poly(ε-caprolactone) substrates were investigated. The substrates were charged under positive corona discharge for 1 min with 5 kV voltage applied to the corona electrode and 1 kV voltage of the same polarity applied to the grid. The dependences on the time of storage of the normalized surface potential of the charged substrates (positive) were investigated. Solutions of 1 % casein in phosphate buffer (pH 8) and 0.1 % chitosan in acetate buffer (pH 5) with added benzydamine hydrochloride were prepared. The creation of the multilayers was carried out by utilizing the technique Layer-by-Layer (LbL). The first built-up layer always possesses an electric charge opposite to that of the substrate. The loading efficiency and drug release kinetics of the chosen model drug were carried out spectrophotometrically.