А COMPLETE NMR DATA ASSIGNMENT FOR THREE DISPIROCOMPOUNDS

Authors

  • Marin Marinov Agricultural University—Plovdiv
  • Dimitar Stoitsov University of Plovdiv "Paisii Hilendarski"
  • Plamen Penchev University of Plovdiv "Paisii Hilendarski"
  • Neyko Stoyanov “Angel Kanchev” University of Ruse

DOI:

https://doi.org/10.59957/jctm.v61.i4.2026.7

Keywords:

1-{2'-oxo-1,1',2',5,6,7-hexahydrospiro[1,5-diazepine-2,3'-indol]-4-yl}-3',4'-dihydro-2'H-spiro[imidazolidine-4,1'-naphthalene]-2,5-dione, 1-{2'-oxo-1',2'-dihydro-5H-spiro[1,5-benzothiazepine-4,3'-indol]-2-yl}-3',4'-dihydro-2'H-spiro[imidazolidine-4,1'-naphthalene]-2,5-dione, 1'-{2'-oxo-1',2'-dihydro-5H-spiro[1,5-benzothiazepine-4,3'-indol]-2-yl}spiro[fluorene-9,4'-imidazolidine]-2',5'-dione, NMR

Abstract

The synthesis of three new dispirocompounds containing imidazolidine dione and isatin fragments as main building blocks each bonded to different ring substituents (i.e. tetraline, 1,4-diazepine, 1,5-benzothiazepine, fluorene) by a spirocarbon was reported. The heterocyclic compounds were obtained with high yields by applying novel and efficient synthetic procedures accompanied with melting point determination. The structures of the synthesized spirocompounds were verified by using a combination of 1D (1H, 13C, DEPT 135) and 2D NMR techniques (1H-1H COSY, HSQC, HMBC). Fully assigned NMR data was presented for each heterocyclic derivative supported by partially assigned ATR-IR data. Cycloalkanespirohydantoins possess anticonvulsant properties similarly to benzothiazepines. Thus, it is expected that the newly synthesized compounds would be biologically active.

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Published

2026-07-01

Issue

Vol. 61 No. 4 (2026)

Section

Articles

License

Copyright (c) 2026 Journal of Chemical Technology and Metallurgy

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